The GABAC receptor is the latest to be identified in retinal neurons. Unlike the GABAA receptor is activated by bicuculline and unlike GABAB is not modulated by baclofen. Apparently GABAC receptor subunits are formed for r being homoligoméricos and have different spatial and functional properties of GABAA receptors and glycine are also abundant in retinal bipolar cells of mammals. In particular, are about 10 times more sensitive than GABA to physiological agonists, show a lower conductance and opening times quite long. Show a high selectivity for Cl-

Receptors for glycine

Glycine is a neutral amino acid whose distribution is much more localized than that of GABA. Glycine inhibits the firing of neurons in the spinal cord and brainstem, but has only a weak effect on neurons of the cerebral cortex. Over 50% of inhibitory synapses in the spinal cord using glycine as an inhibitor, using the remaining GABA.

Glycine is synthesized by serine hidroximetiltransferasa (*), an enzyme present in the mitochondria of spinal motor neurons from serine and stored in synaptic vesicles. Once released into the synaptic cleft, glycine is rapidly eliminated by specific transporters. Mutations in some of these transporters leads to accumulation of glycine in cerebrospinal fluid and blood giving rise to nonketotic hyperglycinemia, neonatal disease characterized by mental retardation, consulviones and drowsiness.