It has been found that GABA is deficient in the cerebrospinal fluid and brain in many experimental and human estudis epilepsy. This deficiency occurs when the enzyme glutamate decarboxylase, which produces GABA from glutamin acid is diminished. The enzyme glutamate decarboxylase is dependent on vitamin B6 and is not surprising that drugs that inhibit vitamin B6 are potent agents causing seizures.

You can use a aprte of vitamin B6 and manganese as a way to raise GABA in the brain. There has been a major study on the GABA and vitamin B6, 50% of the 699 epileptic that were given the supplements showed improvement. Besides vitamin B6 and taurine is needed to produce GABA. Taurine, an amino acid anticonvulsant, is effective in epilepsy because it increases the breakdown of glutamate into GABA.

Kavinace are useful in status epilepticus because can act on GABA receptors.